Knogleerstatning

Bonalive

Bonalive tilbyder en osteostimulerende teknologi med mange unikke og positive egenskaber til regenerering af knogler. Bonalive er det eneste produkt på markedet, der stimulerer knoglevækst og naturligt hæmmer bakterievækst.

Bonalive is a smart biomaterials company, transforming healthcare at the intersection of biology and technology. With over 20 years of clinical history, and one of the most evidence-based technologies in the industry, we are re-imagining a smarter future for healthcare.

Bonalive advances the world’s transition to sustainable solutions for infection treatment and bone regeneration. We envision a world where bone infections can be treated without antibiotics – a smarter world, for a smarter life.

Smart Healing™

Antimicrobial resistance (AMR) is one of the greatest challenges facing healthcare today. In the face of growing resistance, we need solutions to an increasingly complex global problem. Solutions, that are smarter and more sustainable for patients worldwide. Coming to life at the intersection of biology and technology, Smart Healing™ represents a new standard. A new era for patient care. As Smart Healing™ enables increasingly antibiotic free patient care, we provide the world with biomaterial technologies that restore body function through the patient’s own biological processes.

Restoring and sustaining patient life. Together.

For patient wellbeing
To enable a faster recovery time, fewer surgeries and a higher quality of life for patients, Smart Healing™ solutions are comprised of natural biological compounds for use in both adult and pediatric patients.

For professionals
Our solutions aim to minimize the complexity and amount of procedures that medical professionals perform, increasing the capacity of hospital organizations and their personnel to provide better care for more patients.

For global healthcare
procedures that are more costeffective and more sustainable. By aiming to help solve a global problem through improved patient care, Bonalive is committed to creating a better future for the healthcare ecosystem.

Our technology

1. Activation

0–12 DAYS
When Bonalive® bioactive glass is placed into the bone cavity, it reacts with body fluids to activate the granules. During this activation period, the bioactive glass goes through a series of chemical reactions, creating the ideal conditions for bone to rebuild through osteoconduction.

• Na, Si, Ca, and P ions are released.
• A silica gel layer forms on the bioactive glass surface.
• CaP crystallizes, forming a layer of hydroxyapatite on the surface of the bioactive glass.

Picture: Hydroxyap
2. Interaction

6–12 WEEKS
Once the hydroxyapatite layer is formed, the bioactive glass interacts with biological entities, i.e. blood proteins, growth factors and collagen. Following this interactive, osteoconductive and osteostimulative process, new bone grows onto and between the bioactive glass structures.

• Bioactive glass bonds to bone – facilitating new bone formation.
• Osteostimulation begins by stimulating osteogenic cells to increase the remodeling rate of bone.
• Radio-dense quality of bioactive glass allows for post operative evaluation.

Picture: Bonalive® granules bond to bone and stimulate new bone formation.
3. Transformation

MONTHS–YEARS
In the final transformative phase, the process of bone regeneration and remodeling continues. Over time the bone fully regenerates, restoring the patient’s natural anatomy.

• Bone consolidation occurs.
• Bonalive® bioactive glass continues to remodel into bone over a period of years.

Picture: Histological 20 μm-thick section from the mastoid area a few months after Bonalive® granules implantation.