The NanoKnife System from AngioDynamics reimagines localized therapy through its unique mechanism of action, improving precision1, expanding versatility2, and increasing preservation2,3 - giving the physician the control to tailor treatments with confidence4,5. NanoKnife harnesses the power of Irreversible Electroporation (IRE) to effectively destroy targeted cells without the use of thermal energy6 as it delivers high-voltage pulses to create permanent nanopores within the cell membrane. This stimulus induces an apoptotic-like cellular death in the targeted tissue, resulting in a complete ablation7. The NanoKnife System is indicated for the ablation of prostate tissue in patients with intermediate risk prostate cancer.